Download Angiotensin II receptor antagonists : current perspectives by Mancia Giuseppe PDF

By Mancia Giuseppe

Given that angiotensin II is without doubt one of the such a lot effective vasoconstrictors and an incredible stimulus for the secretion of aldosterone from the adrenal gland, the improvement of of angiotensin II inhibitors is a vital step in regulating blood strain. This type of drug is well-tolerated via pateints and those medicines have the further virtue over ACE inhibitors in that they're now not linked to cough. simply because so much medicines should be given as soon as day-by-day and, like ACEIs, they've got an invaluable additive hypotensive influence together with diuretics, they're a welcome healing device within the remedy of high blood pressure. This moment variation builds at the good fortune of the 1st and brings to the reader the entire newest advancements, scientific trial facts, and the contributors's own views while treating sufferers with angiotensin II receptors antagonists.

  • offers chapters via recognized participants within the fields of either high blood pressure and center failure, particularly with reference to pharmacological interventions
  • covers the hot position of AIIR in neuroprotection
  • builds upon the strengths of the 1st edition
  • Show description

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    E. 556 7/3/06 4:06 pm Page 35 Cellular and biological effects of AT2R activation 35 Experiments in AT2R knockout mice Several papers have been published trying to elucidate AT2R function by performing experiments in AT2R knockout mice. 1, compiled from Widdop et al15 and Levy,35 summarizes these partly conflicting results. 36 Consistent with this hypothesis it appears that the beneficial effects of AT2R activation are more pronounced in the FVB/N strain, whereas the C57BL/6 strain seems to be associated with more deleterious effects of AT2R activation.

    2. Johnston CI. Renin–angiotensin system: a dual tissue and hormonal system for cardiovascular control. J Hypertens 1992; 10:S13–26. 3. Peach MJ, Dostal DE. The angiotensin II receptor and the actions of angiotensin II. J Cardiovasc Pharmacol 1990; 16:25–30S. 4. Urata H, Kinoshita A, Misono FS, Bumpus FH, Husain A. Identification of a highly specific chymase as the major angiotensin II forming enzyme in the human heart. J Biol Chem 1990; 265:22348–57. 5. Kleinert HD. Renin inhibition. Cardiovasc Drugs Ther 1995; 9:645–55.

    1,2 Interestingly, the AT2R exhibits some unusual features. e. 1 Direct physical interaction partners of the AT2R. partners to clearly analyze regulatory cascades and networks. 5 The caveats against such a unimodular function of PLZF are discussed below. Furthermore, p85␣ PI3K depends for its activation on growth factors such as EGF, FGF, or IGF4,5 indicating that not AT2R alone is responsible for the observed effects. 10 However, SHP-1 association with the AT2R and SHP-1 activation required the presence of G␣s alone, rather than the G␣␤␥ heterotrimer.

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